TMEM41B acts as an ER scramblase required for lipoprotein ...
May 21, 2021 · Here, we show that TMEM41B, present in the lipoprotein export machinery, encodes a previously conceptualized ER lipid scramblase mediating trans-bilayer shuttling of bulk phospholipids.
Commentary for: a lipid scramblase TMEM41B is involved in the ...
Dec 10, 2024 · Subsequent studies revealed that TMEM41B and VMP1, both of which share a highly conserved DedA domain, function as an ER-resident lipid scramblase that regulates the distribution …
Chen and colleagues showed that TMEM41B encodes an ER lipid scramblase and executes a produce-and-protect mechanism for ER function and integrity. Deficiency of TMEM41B triggers severe …
The scramblases VMP1 and TMEM41B are required for primitive ...
Dec 18, 2024 · Our findings identify the role of the lipid scramblases VMP1 and TMEM41B in WNT signaling during extra-embryonic endoderm development and characterize their distinct and …
In vitro and in vivo assay of the ER lipid scramblase TMEM41B
Apr 19, 2022 · Here, we present a protocol for assessing the activity of the ER-localized lipid scramblase TMEM41B. We detail an in vitro fluorescent liposome-based phospholipid scrambling assay and in …
In vitro and in vivo assay of the ER lipid scramblase TMEM41B
Jun 17, 2022 · Amphipathic phospholipids translocated by scramblases play a central role in facilitating lipid movement across the membrane bilayer, especially at the endoplasmic reticulum (ER) …
Representative results (n = 3 independent experiments) showing that reintroduction of CRISPR-resistant TMEM41B eliminates lipid accumulation induced by Tmem41b deficiency (n = 8 for each group).