Oct 7, 2009 · These results suggest that DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission.

Conclusion: These results suggest that DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission.

Oct 7, 2009 · However, in placenta containing low levels of DC-SIGNR, HIV-1 would preferentially binds CCR5 on endothelial cells resulting in a loss of placental barrier integrity and enhanced passage of …

The exon 4 protein-modifying mutations increased HIV-1 capture and transmission to T cells in vitro. This study provides compelling evidence to support an important role of DC-SIGN in IU HIV-1 infection.

Other factors which increase the risk of postnatal HIV transmission include maternal nipple lesions, mastitis, low maternal CD4+ T cell count, infant oral thrush and breastfeeding for longer than 15 …

This suggested that the level of mother-infant concordance may compromise the child’s capacity to control HIV-1 replication when the virus is acquired from the mother.

Jul 10, 2012 · Dendritic cell–specific ICAM-3 grabbing-nonintegrin (DC-SIGN, also known as CD209) is an HIV-1 receptor that enhances its transmission to T cells and is expressed on placental …

These results suggest that DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission.

The dendritic cell (DC)-specific HIV-1 receptor DC-SIGN plays a key-role in the dissemination of HIV-1 by DCs. DC-SIGN captures HIV-1 at sites of entry, enabling its transport to lymphoid tissues, where …

CONCLUSION: These results suggest that DC-SIGNR plays a crucial role in MTCT of HIV-1 and that impaired placental DC-SIGNR expression increases risk of transmission.