Nov 10, 2000 · Serial passage of initially nonlethal Ebola virus (EBOV) in outbred guinea pigs resulted in the selection of variants with high pathogenicity. Nucleotide sequence analysis of the complete …

Nov 1, 2000 · Share this article Abstract Serial passage of initially nonlethal Ebola virus (EBOV) in outbred guinea pigs resulted in the selection of variants with high pathogenicity. Nucleotide …

Nov 1, 2011 · Furthermore, we demonstrate that both VP24/wild type and the guinea pig–adapted VP24/8mc are similar in their ability to block expression of interferon-induced host genes, suggesting …

Furthermore, we demonstrate that both VP24/wild type and the guinea pig–adapted VP24/8mc are similar in their ability to block expression of interferon-induced host genes, suggesting that the ...

The research shows that amino acid changes in VP24 are both necessary and sufficient to increase EBOV virulence in guinea pigs, specifically mutations M71I, L147P, and T187I confirmed increased …

Here, we provide an overview of our several adaptation series in guinea pigs, which resulted in the establishment of guinea pig-adapted EBOV (GPA-EBOV) variants different in their characteristics, …

Here, we provide an overview of our several adaptation series in guinea pigs, which resulted in the establishment of guinea pig-adapted EBOV (GPA-EBOV) variants diferent in their characteristics, …

Eight guineapigs were aerosolized with guineapig-adapted Zaire ebolavirus (variant: Mayinga) and developed lethal interstitial pneumonia that was distinct from lesions described in guineapigs …

The guinea pig-adapted EBOV is causing a lethal infection with minor manifestations in the first 4-5 days and a subsequent rapid development of a highly febrile condition resulting in the animal death on …