May 14, 2021 · • Identify new onset of unexplained large-volume, frequent, liquid diarrhea and consider a broad differential diagnosis. This process of medical decision-making is unchanged. • If testing is …
Clinical Testing and Diagnosis for C. diff Infection
Mar 6, 2024 · There are four laboratory tests used to diagnose Clostridioides difficile infection or CDI. Hospitals are required to report C. diff infections. FDA-approved PCR assays are same-day tests …
When there is concern for CDI, order the C difficile toxin assay. The GI pathogen PCR panel (GIP) should not be used as a method for screening for C. difficile and should be reserved for patients …
Clostridioides (Clostridium) difficile Infection Testing Algorithm
A step-by-step flow chart designed to assist physicians in choosing the right test for Clostridioides (Clostridium) difficile Infection Testing Algorithm
Multistep Testing Algorithms for Clostridioides difficile Infection
Multistep CDI test algorithms include a sensitive stool screening test such as a nucleic acid amplification test (NAAT) or glutamate dehydrogenase (GDH) antigen testing and a more specific test, enzyme …
Our current testing algorithm for laboratory diagnosis of C. difficile disease utilizes an Enzyme Immunoassay (EIA) for detection of Toxin and GDH (a non-specific marker for C. difficile) followed by …
The new test is a multistage test that first looks for the toxin gene by PCR (just like the old test) but then, if the gene is present (“PCR Positive), the second test looks for active production of the toxin (“PCR …
Oct 3, 2025 · On July 19, 2023, working with the Diagnostic Stewardship Committee under Dr. Deborah Rhodes, YNHHS converted to a testing algorithm used successfully by many of our peers: screening …
The decision to use either standalone NAAT or 2-step algorithm must be made at the institutional level. Both approaches have pros/cons and are supported by current guidelines.
Systemwide Algorithmic Approach to C. diff Testing
Working through the health system’s core laboratory, Alverno, and using best practice guidelines, Dr. Atkinson and the rest of the utilization management committee laid out a systemwide initiative to …