The present study was initiated by comparing publicly available transcription profiles of tumor tissues from responsive and resistant ICB-treated patients across various cancer types.

5 days ago · Predicting tumor progression is one of the major challenges in oncology. Scientists at the University of Geneva (UNIGE) and the Ludwig Institute for Cancer Research have discovered that ...

Jan 4, 2026 · Immune checkpoints play pivotal roles in regulating immune responses and maintaining tolerance. In cancer, these molecules are hijacked to suppress antitumor immunity, resulting in …

Dec 16, 2025 · Even if a T-cell recognizes a cancer cell, the tumor employs a second strategy to shut down the immune attack through molecular signaling. This involves exploiting natural “brakes” in the …

In contrast, cold tumors are characterized by defective antigen presentation, upregulation of immune checkpoint molecules such as PD-L1, and enrichment of immunosuppressive cell populations, …

5 days ago · A research team from Université de Genève has revealed how the 'hijacking' of neutrophils, a type of immune cell, promotes cancer growth and could provide insights into disease progression.

6 days ago · The tumor microenvironment is a complex and dynamic ecosystem, where cancer cells coexist with diverse populations of immune and stromal cells, each influencing — and sometimes …

Discover how cancer cells bypass immune defenses and explore innovative strategies to combat the disease through scientific insights and therapeutic approaches.

May 10, 2024 · Authors note that tumors likely employ a variety of strategies to evade immune detection. But the discovery could lead to a new approach for targeted cancer therapies.

Mar 22, 2024 · In summary, EV PD-L1 affects both immune cells and tumor cells, leading to the suppression of anti-tumor immunity and promotion of tumor progression. These processes ultimately …